![]() ![]() It competitively inhibits the activity at the benzodiazepine receptor site on the GABA/benzodiazepine receptor complex. Flumazenil is the reversal agent for benzodiazepines. While edoxaban (Savaysa) is also a factor Xa inhibitor, andexanet alfa is not FDA-approved to reverse its activity.Īnswer C is correct. ![]() ![]() It works by binding the factor Xa inhibitors and also increases tissue factor-initiated thrombin generation. Andexanet alfa is the agent FDA-approved for life-threatening bleeding associated with apixaban (Eliquis) and rivaroxaban (Xarelto), both of which are factor Xa inhibitors. Idarucizumab is a monoclonal antibody fragment that specifically binds dabigatran and its metabolites. When vitamin K is given IV, it should be administered by slow infusion to minimize risk of anaphylaxis.Īnswer B is incorrect because the reversal agent for dabigatran is idarucizumab (Praxbind). Normally, it is given when INR is > 10 and/or significant bleeding is present. Pesticides - reproductive health.Which of the following correctly matches the drug with its antidote/reversal agent? Select all that apply.īecause warfarin is a vitamin K antagonist, phytonadione (vitamin K) can be given as an antidote, making answer A correct. Environmental Protection Agency 2013:173-187.Ĭenters for Disease Control and Prevention. In: Recognition and Management of Pesticide Poisonings. Long-acting anticoagulant rodenticide (superwarfarin) poisoning: a review of its historical development, epidemiology, and clinical management. 2017 annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 35th annual report. A successfully treated case of criminal thallium poisoning. Yumoto T, Tsukahara K, Naito H, Iida A, Nakao A. Human bromethalin exposures reported to a U.S. Huntington S, Fenik Y, Vohra R, Geller RJ. First aid interventions by laypeople for acute oral poisoning. CONTRAC All-Weather BLOX.Īvau B, Borra V, Vanhove AC, Vandekerckhove P, De Paepe P, De Buck E. Effects of bromadiolone poisoning on the central nervous system. Wang M, Yang Y, Hou Y, Ma W, Jia R, Chen J. ![]() Treasure Island (FL): StatPearls Publishing 2022. Recognition and management of pesticide poisonings: rodenticides. ![]()
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